Anti-Allergic Effect of Aqueous Extract of Coriander (Coriandrum sativum L.) Leaf in RBL-2H3 Cells and Cedar Pollinosis Model Mice

Coriander (Coriandrum sativum L.) is classified in the Apiaceae family and used as an herb. leaf has been reported to possess various health functions. Here, we report anti-allergic effect of aqueous coriander extract (ACLE). ACLE with 1.0 mg/mL or higher concentration significantly inhibited degranulation RBL-2H3 cells a concentration-dependent manner no cytotoxicity. suppressed increase intracellular Ca2+ response antigen-specific stimulation. Immunoblot analysis demonstrated that downregulates phosphorylation phosphatidylinositol 3-kinase tends downregulate Syk kinase signaling pathways activated by antigen-mediated Oral administration did not alter sneezing frequency pollinosis model mice stimulated cedar pollen, but reduced serum IgE level. Our data show effects both cultured mice. These results suggest potential be functional foodstuff anti-allergy effects.